When less is more: ‘slicing’ sequencing data improves read decoding accuracy andde novoassembly quality
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چکیده
منابع مشابه
When less is more: 'slicing' sequencing data improves read decoding accuracy and de novo assembly quality
MOTIVATION As the invention of DNA sequencing in the 70s, computational biologists have had to deal with the problem of de novo genome assembly with limited (or insufficient) depth of sequencing. In this work, we investigate the opposite problem, that is, the challenge of dealing with excessive depth of sequencing. RESULTS We explore the effect of ultra-deep sequencing data in two domains: (i...
متن کاملSequence analysis When less is more: ‘slicing’ sequencing data improves read decoding accuracy and de novo assembly quality
Motivation: As the invention of DNA sequencing in the 70s, computational biologists have had to deal with the problem of de novo genome assembly with limited (or insufficient) depth of sequencing. In this work, we investigate the opposite problem, that is, the challenge of dealing with excessive depth of sequencing. Results: We explore the effect of ultra-deep sequencing data in two domains: (i...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2015
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btv311